Quadruple DNA helix discovered in human cells

Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.

Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.

The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.

Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.

"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.

Tagged with antibodies

Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.

This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.

"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.

"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.

Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.

Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548

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Football: Madrid hand Valencia five-goal thrashing

MADRID: Real Madrid put their dismal first half of the season behind them as they tore Valencia apart for the first 45 minutes to win 5-0 and ease the pressure on coach Jose Mourinho.

Cristiano Ronaldo and Angel Di Maria both hit braces and Gonzalo Higuain was also on target in a first-half goal romp.

But there is still little hope of them retaining their title as they trail Barcelona by 15 points despite the Catalan side losing 3-2 against Real Sociedad on Saturday, their bitter rivals' first league defeat of the season.

They are also seven points off neighbours Atletico Madrid who beat Levante 2-0 earlier Sunday.

Madrid arrived at the Mestalla having beaten Valencia 2-0 in a stormy Spanish Cup quarter-final first leg tie in mid-week and Mourinho decided against resting players ahead of the second leg on Wednesday.

There has been plenty of tension in the Madrid camp following their poor form but there were no repercussions from an argument between Mourinho and Ronaldo after the first leg of the cup.

Furthermore, Iker Casillas was preferred in goal to Adan Garrido who had controversially replaced the Spain international before being suspended.

Still they had important absentees at the back with Pepe, Sergio Ramos and Marcelo all missing and they faced a rejuvenated Valencia side under Ernesto Valverde who had won their previous three league games.

After a cagey opening spell Madrid were suddenly presented with a gift for Higuain which he failed to take advantage of in front of goal.

He was left unmarked but side-footed an Alvaro Arbeloa cross wide from six yards.

Higuain was given the chance to make amends a minute later and this time made no mistake. Again it was a case of poor defending as Di Maria scampered clear and set up Higuain who slotted into the corner.

Valencia attempted to respond but they fell apart midway through the first half as their defence was once again exposed.

Keeper Diego Alves twice denied Sami Khedira and Raphael Varane headed wide from a corner before Di Maria got the second.

Ronaldo teased makeshift right-back Ricardo Costa, standing in for Joao Pereira, and crossed for the Argentine to tuck the ball home from close range.

Valencia were in disarray at the back and Ronaldo split them open again as he burst into the left of the area and beat Alves at his near post.

Ronaldo got his second after 41 minutes when he cracked in an Ozil pass from 12 yard and then Ozil was again the provider as he put Di Maria clear for the fifth still before half-time.

Valencia showed character to come back at Madrid after the restart with Pablo Piatti hitting the crossbar and Adil Rami had a header cleared off the line by Fabio Coentrao but Madrid remained organised and managed to keep a clean sheet.

Atletico Madrid equalled their best ever winning streak at home in La Liga in a memorable season for the club with their win over Levante.

Goals from Adrian Lopez and Jorge Resurrecion 'Koke' saw Atletico win their 12th straight league game at the Calderon and match the club record dating back to a run between the 1939-40 and 1940-41 seasons.

Elsewhere on Sunday, Osasuna beat Deportivo La Coruna 2-1 and Valladolid won 2-0 against Zaragoza.

-AFP/ac

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Schmidt, daughter open up about trip to North Korea

Google's Eric Schmidt (right) arrives in North Korea on January 7 with former New Mexico Gov. Bill Richardson.

(Credit:
CBS News/Screenshot by CNET)

Google's Eric Schmidt is back from his much-publicized trip to North Korea, and he's got a few details to share about his humanitarian mission.

The search giant's executive chairman had already revealed some of the reasoning behind his trip to reporters during a briefing a week and a half ago at the Beijing airport, saying that his private delegation urged North Korean officials to open up global Internet access if they wanted to strengthen their economy. The delegation was led by former New Mexico Gov. Bill Richardson, who is also a former ambassador to the U.N.

In a post last night on his Google+ page, Schmidt opened up more about his thoughts on Internet access in the country, explaining that North Korea's decision to essentially isolate itself from the global Net is going to "make it harder for them to catch up economically."

He noted that while Internet access is possible for government officials and the military and while there is a private intranet set up for universities, the general public does not have access to the Internet unless someone is watching them.

Furthermore, he said that it was obvious that the country's technology is limited. "There is a 3G network that is a joint venture with an Egyptian company called Orascom. It is a 2100 Megahertz SMS-based technology network, that does not, for example, allow users to have a data connection and use smart phones," he wrote.

A separate blog post written by Schmidt's daughter Sophie, who accompanied him on the trip, included even more details of their visit, along with a series of photos. She described the country as "very, very cold" and "very, very strange."

"Nothing I'd read or heard beforehand really prepared me for what we saw," she wrote.

The delegation apparently visited the Palace of the Sun, Kim Il Sung's former office and now the national mausoleum where Kim Il Sung's and Kim Jong Il's bodies lie in state, as well as the Kim II Sung University e-Library, which she described eerily as a room of 90 desks, all manned, with just one problem: "No one was actually doing anything. A few scrolled or clicked, but the rest just stared."

Some other interesting tidbits from her post:

• We left our phones and laptops behind in China, since we were warned they'd be confiscated in NK, and probably infected with lord knows what malware.
• Our trip was a mixture of highly staged encounters, tightly-orchestrated viewings and what seemed like genuine human moments. We had zero interactions with non-state-approved North Koreans and were never far from our two minders (2, so one can mind the other).
• Ordinary North Koreans live in a near-total information bubble, without any true frame of reference.
• We were told well ahead of time to assume that everything was bugged: phones,
  cars, rooms, meetings, restaurants and who knows what else.
• This is a country in a permanent revolutionary state, and everything you see reflects that dug-in, determined, fiercely independent quality.
• Their mobile network, Koryolink, has between 1-2 million subscribers. No data service, but international calls were possible on the phones we rented. Realistically, even basic service is prohibitively expensive, much like every other consumption good (fuel, cars, etc.).
• North Korea has a national intranet, a walled garden of scrubbed content taken from the real Internet. Our understanding is that some university students have access to this.
  

The State Department had frowned upon the group's visit to the country, saying that the timing wasn't right. A department spokeswoman cited recent missile launches by North Korea as a reason for discouraging the mission.

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Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

Read More..

Sasha's View: 'Good Job, Daddy. You Didn't Mess Up'

President Barack Obama and Vice President Joe Biden today officially embarked on their second term, taking the Constitutionally mandated oath of office in two separate private ceremonies inside their homes.

Shortly before noon in the Blue Room of the White House, Obama raised his right hand, with his left on a family Bible, reciting the oath administrated by Chief Justice John Roberts. He was surrounded by immediate family members, including first lady Michelle Obama and daughters, Malia and Sasha.

As he hugged his wife and daughters, Sasha said, "Good job, Daddy."

"I did it," he said.

"You didn't mess up," she answered.

Biden was sworn in earlier today by Justice Sonia Sotomayor, the first Hispanic to administer a presidential oath, in a ceremony at his official residence at the U.S. Naval Observatory. He was joined by more than 120 guests, including cabinet members, extended family and his wife, Dr. Jill Biden.

Because Jan. 20 -- the official date for a new presidential term -- falls on a Sunday this year, organizers delayed by one day the traditional public inauguration ceremony and parade down Pennsylvania Avenue.

Vice President Joe Biden Sworn in for 2nd Term Watch Video

President Obama's 2nd Inauguration: Hundreds of Thousands to Attend Watch Video

Obama and Biden will each repeat the oath on Monday on the west front of the Capitol, surrounded by hundreds of dignitaries and members of Congress. An estimated 800,000 people are expected to gather on the National Mall to witness the moment and inaugural parade to follow.

The dual ceremonies in 2013 means Obama will become the second president in U.S. history to take the presidential oath four times. He was sworn in twice in 2008 out of an abundance of caution after Roberts flubbed the oath of office during the public administration. This year Roberts read from a script.

Franklin Roosevelt was also sworn in four times but, unlike Obama, he was elected four times.

This year will mark the seventh time a president has taken the oath on a Sunday and then again on Monday for ceremonial purposes. Reagan last took the oath on a Sunday in 1985.

Both Obama and Biden took the oath using a special family Bible. Obama used a text that belonged to Michelle Obama's grandmother LaVaughn Delores Robinson. Biden placed his hand on a 120-year-old book with a Celtic cross on the cover that has been passed down through Biden clan.

The official inaugural activities today also included moments of prayer and remembrance that marked the solemnity of the day.

Obama and Biden met at Arlington National Cemetery for a brief morning ceremony to place a wreath on the Tomb of the Unknowns, honoring military service members who served and sacrificed. The men stood shoulder to shoulder, bowing their heads as a bugler played "Taps."

Biden, who is Catholic, began the day with a private family mass at his residence. The president and first family attended church services at Metropolitan African Methodist Episcopal Church, a historically black church and site of two pre-inaugural prayer services for former President Bill Clinton and Vice President Al Gore and their families.

The Obamas and Bidens plan to participate in a church service on Monday morning at St. John's Episcopal, across Lafayette Park from the White House. They will also attend a National Prayer Service on Tuesday at the National Cathedral.

Later on Sunday evening, the newly-inaugurated leaders will attend a candlelight reception at the National Building Museum. The president and vice president are expected to deliver brief remarks to their supporters.

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Earth may be crashing through dark matter walls

Earth is constantly crashing through huge walls of dark matter, and we already have the tools to detect them. That's the conclusion of physicists who say the universe may be filled with a patchwork quilt of force fields created shortly after the big bang.

Observations of how mass clumps in space suggest that about 86 per cent of all matter is invisible dark matter, which interacts with ordinary matter mainly through gravity. The most popular theory is that dark matter is made of weakly interacting massive particles.

WIMPs should also interact with ordinary matter via the weak nuclear force, and their presence should have slight but measurable effects. However, years of searches for WIMPs have been coming up empty.

"So far nothing is found, and I feel like it's time to broaden the scope of our search," says Maxim Pospelov of the University of Victoria in Canada. "What we propose is to look for some other signatures."

Bubbly cosmos

Pospelov and colleagues have been examining a theory that at least some of the universe's dark matter is tied up in structures called domain walls, akin to the boundaries between tightly packed bubbles. The idea is that the hot early universe was full of an exotic force field that varied randomly. As the universe expanded and cooled, the field froze, leaving a patchwork of domains, each with its own distinct value for the field.

Having different fields sit next to each other requires energy to be stored within the domain walls. Mass and energy are interchangeable, so on a large scale a network of domain walls can look like concentrations of mass – that is, like dark matter, says Pospelov.

If the grid of domain walls is packed tightly enough – say, if the width of the domains is several hundred times the distance between Earth and the sun – Earth should pass through a domain wall once every few years. "As a human, you wouldn't feel a thing," says Pospelov. "You will go through the wall without noticing." But magnetometers – devices that, as the name suggests, measure magnetic fields – could detect the walls, say Pospelov and colleagues in a new study. Although the field inside a domain would not affect a magnetometer, the device would sense the change when Earth passes through a domain wall.

Dark matter walls have not been detected yet because anyone using a single magnetometer would find the readings swamped by noise, Pospelov says. "You'd never be able to say if it's because the Earth went through a bizarre magnetic field or if a grad student dropped their iPhone or something," he says.

Network needed

Finding the walls will require a network of at least five detectors spread around the world, Pospelov suggests. Colleagues in Poland and California have already built one magnetometer each and have shown that they are sensitive enough for the scheme to work.

Domain walls wouldn't account for all the dark matter in the universe, but they could explain why finding particles of the stuff has been such a challenge, says Pospelov.

If domain walls are found, the news might come as a relief to physicists still waiting for WIMPs to show up. Earlier this month, for instance, a team working with a detector in Russia that has been running for more than 24 years announced that they have yet to see any sign of these dark matter candidates.

Douglas Finkbeiner of the Harvard-Smithsonian Center for Astrophysics, who was not involved in Pospelov's study, isn't yet convinced that dark matter walls exist. But he is glad that physicists are keeping an open mind about alternatives to WIMPs.

"We've looked for WIMP dark matter in so many ways," he says. "At some point you have to ask, are we totally on the wrong track?"

Journal reference: Physical Review Letters, DOI: 10.1103/PhysRevLett.110.021803

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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Football: Pogba at double for Juve as Palermo hold Lazio

MILAN: French teenager Paul Pogba scored a sensational brace to inspire depleted Juventus to a 4-0 rout of Udinese which helped the Serie A champions extend their lead over Lazio on Saturday.

Juve started their 21st match of the campaign with a three-point lead on both Napoli and Lazio but missing key midfielders Andrea Pirlo, Claudio Marchisio and Arturo Vidal due to recent injuries.

After Lazio had to settle for a share of the points in a 2-2 draw at strugglers Palermo, Juve took full advantage.

The champions now have a five-point lead over Lazio, who sit second on 43 points, and will be hoping Napoli, third on 42, find similar trouble Sunday in their away game against Fiorentina.

Pogba, signed in the off-season on a free transfer from Manchester United, had already scored two sensational goals earlier this season.

And the 19-year-old broke the deadlock near the end of a frustrating first half for the hosts by unleashing a 30-metre screamer which hit the crossbar before beating Daniele Padelli in the Udinese goal.

Juventus were struggling to build on their lead in the early stages of the second half when Udinese were unlucky not to score on the counter.

But again Pogba came to the rescue, this time with a long-range daisy-cutter which slotted into Padelli's bottom corner to give Juve a 2-0 lead.

Six minutes later Juve striker Mirko Vucinic made it 3-0 when Padelli parried the Montenegrin's close-range effort over his own body and into the net.

Udinese threatened through top striker Antonio Di Natale, who saw a snapshot shave the top of the crossbar.

However the former Italy striker appeared to be showing the effects of recent flu-like symptoms, which meant he only appeared early in the second half.

With 10 minutes to play, second half substitute Alessandro Matri made it 4-0 for the hosts when he latched on to a Vucinic through ball to nutmeg Padelli.

Despite missing Miroslav Klose, Abdoullay Konko and Ederson, Lazio had hoped to secure a win that would have kept them three points behind Antonio Conte's league leaders.

But after Vladimir Petkovic's side were stunned by two goals in less than two minutes the visitors were forced to launch a late fighback to grab a share of the points

Sergio Floccari gave Lazio a 10th minute lead when he headed Cristian Ledesma's cross over the static Samir Ujkani in the Palermo goal, only for Arevalo Rios (70) and Paulo Dybala (71) to give the hosts a shock lead.

It took a penalty from Brazilian Hernanes, after Floccari had been fouled in the box, for Lazio to draw level with six minutes left to play.

- AFP/de

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Microsoft blazes trail to next PC

Microsoft Surface Pro: the design isn't perfect, but the fact that it can function as a standalone tablet and is thin and light puts it ahead of the convertible-laptop pack.

(Credit:
CNET)

PC makers take note. Microsoft is pioneering the next PC.

Here are two simple reasons why the Surface Pro makes a good case as the template for the new PC. One, Microsoft realized that the device's electronics should go behind the glass, not under the keyboard. Two, the device uses a real processor.

Let's address the electronics first. Most of the newfangled laptops I saw at
CES were convertibles. That is, the displays are not detachable because the core electronics are under the keyboard, just like your father's laptop.

And most of them were unimpressive. The mechanics necessary to flip and/or slide the screen and convert the laptop to
tablet mode were more often than not kludgy and some seemed destined for mechanical problems down the pike.

And the more problematic designs weren't thin or light, either. At least not when compared with popular tablets like Apple's
iPad or Google's Nexus.

One of the few exceptions -- as I noted before -- was the HP EliteBook Revolve. That 11.6-inch design was about as well conceived as a convertible can be.

But there's a reason for that: HP has been building Windows convertibles for ages. The EliteBook 2700 series has been around since the dawn of Windows XP. So, HP has this down to a science.

But, again, that's a rare exception at present. The future leans more toward a PC with the electronics behind the glass. And there's no better example right now than the Surface Pro.

Microsoft was bold enough to go with a mainstream third-generation Core Intel "Ivy Bridge" chip, not the slower Atom processor that most Windows 8 tablet and detachable makers have opted for.

Yeah, the battery life won't be great, but Microsoft, I think, knew (rightly so) that it would be crucified if it opted for the performance-challenged Atom chip, which isn't up to the task of running serious desktop applications on Windows 8.

Remember the netbook? That's one way to look at the first crop of Atom-based Windows 8 tablets: a netbook in tablet clothing. Microsoft didn't want to go there.

And give Lenovo some credit too. It showed off the ThinkPad Helix detachable at CES that separates from the base to become a full-fledged Ivy Bridge-based tablet, not unlike the Microsoft Surface Pro.

And Intel, I think, in its heart of hearts knows Atom isn't really up to the task. Thus, the revelation at CES of the most power-efficient Ivy Bridge yet. One of Intel's goals is to get these new Ivy Bridge chips -- as well as upcoming "Haswell" chips -- behind the glass, as Intel's Adam King told me at CES.

So, I would expect to see an increasing number of Windows 8 tablets and/or detachables sporting Intel's mainstream Haswell Core processors later this year.

And battery life will improve with Haswell. I would be fine with a Windows 8 tablet packing a real Intel chip that gets six hours of battery life. And a Haswell-based Surface tablet should meet or exceed this.

Sony Vaio Duo 11 convertible: The apparatus to support the display in tablet mode isn't exactly elegant.

(Credit:
CNET)

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Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

Read More..

Ex-Teammate: Armstrong Showed 'Genuine Emotion'

While critics railed against Lance Armstrong for coming off as detached in the two-part interview with Oprah Winfrey that aired Thursday and Friday nights, former teammate and friend, Tyler Hamilton, told "Good Morning America" today that he felt Armstrong was displaying "genuine emotion."

"I've never seen Lance shed a tear until last night. Before I even heard one word from him Thursday night, I could tell he was a broken man," Hamilton said.

Armstrong's contrition turned tearful Friday when he revealed to Oprah Winfrey how difficult it was to betray his family -- particularly his 13 year old son -- who stood up for the fallen cycling star as rumors swirled that he was taking banned drugs.

Armstrong, 41, choked up when he recounted what he told his son, Luke, in the wake of the scandal.

"When this all really started, I saw my son defending me and saying that's not true…" Armstrong told Winfrey, "I told Luke. I said, 'Don't defend me anymore.'"

Armstrong's interview with Winfrey drew millions of viewers.

It was the first time Armstrong admitted using performance-enhancing drugs and oxygen-boosting blood transfusions to help him win the Tour de France.

"I view this situation as one big lie that I repeated a lot of times," Armstrong said. "I know the truth. The truth isn't what was out there. The truth isn't what I said.

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"I'm a flawed character, as I well know," Armstrong added. "All the fault and all the blame here falls on me."

However, Hamilton said any hope for Armstrong's redemption would come if he came clean about others who were part of the doping scandal.

"The question now is where he goes from this, his actions moving forward. He needs to name names," Hamilton said.

READ MORE: Armstrong Admits to Doping

Armstrong was stripped of his seven Tour de France titles in October 2012, after a report by the U.S. Anti-Doping Agency found that he and 11 of his teammates orchestrated "the most sophisticated, professionalized and successful doping program that sport has ever seen."

Despite the admissions of his teammates that they had doped with Armstrong and seen him complete blood transfusions for races, Armstrong condemned the report and denied that he had ever cheated.

As sponsors including Nike began to pull support of Armstrong following the report, Armstrong's carefully-built image began to crumble. He stepped down from Livestrong, the charity he started to help cancer patients after he survived testicular cancer.

"It was a mythic perfect story and it wasn't true," Armstrong said of his fairytale story of overcoming testicular cancer to become the most celebrated cyclist in history.

In the interview, Armstrong explained his competition "cocktail" of EPO, blood transfusions and testosterone that he used throughout his career. He also said he had previously used cortisone.

Armstrong refused to give Winfrey the details of when, where and with whom he doped during seven winning Tours de France between 1999 and 2005, which was the last year he said he doped. Armstrong specifically denied using banned substances when he placed third in 2009 and entered the tour again in 2010.

Investigators familiar with Armstrong's case, however, told ABC News that Armstrong did not come completely clean to Winfrey, and say they believe he doped in 2009.

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